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Infigratinib靶向的FGFR3（成纤维细胞生长因子受体3）正是驱动ACH疾病发生的关键靶点，2月12日，BridgeBio公布Infigratinib在ACH中取得的首个具有统计学显著改善意义的3期顶线结果，公司计划下半年向FDA提交新药申请。
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Stewart Brand thinks big and long. He thinks on a planetary scale – as suggested by the title of his celebrated Whole Earth Catalog – and on the longest of timeframes, as with his Long Now Foundation, which looks forward to the next 10,000 years of human civilisation. He has had a lifelong fascination with the future, and anything that could get us there faster, from space travel to psychedelic drugs to computing. In fact, he was arguably the bridge between the San Francisco counterculture of the 60s and present-day Silicon Valley: in his commencement speech at Stanford University in 2005, Steve Jobs eulogised the Whole Earth Catalog and Brand’s philosophy, and echoed its farewell mantra: “Stay hungry. Stay foolish.”
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